Most Seasons Leading League
| 2 | Cookie Gilchrist | Buffalo (1962, 64) |
| Jim Nance | Boston (1966-67) | |
| 1 | Abner Haynes | Dallas (1960) |
| Billy Cannon | Houston (1961) | |
| Clem Daniels | Oakland (1963) | |
| Paul Lowe | San Diego (1965) | |
| Paul Robinson | Cincinnati (1968) | |
| Dick Post | San Diego (1969) |
Most Attempts, Lifetime
| 1134 | Clem Daniels | Dallas (1960) |
| Oakland (1961-67) | ||
| 1049 | Jim Nance | Boston (1965-69) |
| 1044 | Bill Mathis | New York (1960-69) |
Most Attempts, Season
| 299 | Jim Nance | Boston (1966) |
| 269 | Jim Nance | Boston (1967) |
| 252 | Cookie Gilchrist | Denver (1965) |
Most Attempts, Game
| 38 | Jim Nance | Boston vs. Oakland | October 30, 1966 (208 yards) |
| 36 | Cookie Gilchrist | Buffalo vs. New York | December 8, 1963 (243 yards) |
| 34 | Jim Nance | Boston vs. Buffalo | September 24, 1967 (185 yards) |
Most Yards Gained, Lifetime
| 5101 | Clem Daniels | Dallas (1960) |
| Oakland (1961-67) | ||
| 4995 | Paul Lowe | L.A.-S.D. (1960-68) |
| Kansas City (1968-69) | ||
| 4630 | Abner Haynes | Dal.-K.C. (1960-64) |
| Denver (1965-66) | ||
| Miami (1967) | ||
| New York (1967) |
Most Yards Gained, Season
| 1458 | Jim Nance | Boston (1966) |
| 1216 | Jim Nance | Boston (1967) |
| 1194 | Hoyle Granger | Houston (1967) |
Most Yards Gained, Game (200+ Yards)
| 243 | Cookie Gilchrist | Buffalo vs. New York | December 8, 1963 (36 attempts) |
| 216 | Billy Cannon | Houston vs. New York | December 10, 1961 (25 attempts) |
| 208 | Jim Nance | Boston vs. Oakland | October 30, 1966 (38 attempts) |
| 200 | Clem Daniels | Oakland vs. New York | October 20, 196 (27 attempts) |
Most Games 100+ Yards, Lifetime
| 17 | Jim Nance | Boston (1966-69) |
| 15 | Paul Lowe | L.A.-S.D. (1960-66) |
| 14 | Abner Haynes | Dal.-K.C. (1960-64) – 13 |
| Denver (1965-66) – 0 | ||
| Miami (1967) – 1 | ||
| New York (1967) – 0 | ||
| Clem Daniels | Oakland (1961-67) |
Most Games 100+ Yards, Season
| 8 | Jim Nance | Boston (1966) |
| 7 | Hoyle Granger | Houston (1967) |
| 6 | Cookie Gilchrist | Buffalo (1962) |
| Jim Nance | Boston (1967) |
Longest Run from Scrimmage
| 91 | Sid Blanks | Houston vs. New York | December 13, 1964 (TD) |
| 87 | Jack Larscheid | Oakland vs. Boston | October 16, 1960 (TD) |
| Paul Lowe | San Diego vs. Dallas | September 10, 1961 (TD) | |
| Paul Robinson | Cincinnati vs. Oakland | October 27, 1968 (TD) | |
| 86 | Keith Lincoln | San Diego vs. Oakland | September 30, 1962 (TD) |
Highest Average Gain, Lifetime (700 attempts)
| 4.87 | Paul Lowe | L.A.-S.D. (1960-68) |
| Kansas City (1968-69) | ||
| 4.50 | Clem Daniels | Dallas (1960) |
| Oakland (1961-67) | ||
| 4.46 | Keith Lincoln | San Diego (1961-66, 68) |
| Buffalo (1967-68) |
Highest Average Gain, Season (100 attempts)
| 6.45 | Keith Lincoln | San Diego (1963) |
| 6.29 | Paul Lowe | Los Angeles (1960) |
| 5.71 | Paul Lowe | San Diego (1963) |
Highest Average Gain, Game (10 attempts)
| 13.83 | Keith Lincoln | San Diego vs. Oakland | September 30, 1962 |
| 13.45 | Wray Carlton | Buffalo vs. Houston | December 5, 1965 |
| 12.7 | Keith Lincoln | San Diego vs. Kansas City | October 20, 1963 |
M0st Touchdowns Rushing, Lifetime
| 46 | Abner Haynes | Dal.-K.C. (1960-64) – 39 |
| Denver (1965-66) – 5 | ||
| Miami (1967) – 2 | ||
| 40 | Jack Kemp | L.A.-S.D. (1960-62) – 15 |
| Buffalo (1962-69) – 25 | ||
| 39 | Paul Lowe | L.A.-S.D. (1960-68) – 39 |
Most Touchdowns Rushing, Season
| 13 | Cookie Gilchrist | Buffalo (1962) |
| Abner Haynes | Dallas (1962) | |
| 12 | Cookie Gilchrist | Buffalo (1963) |
| 11 | Jim Nance | Boston (1966) |
Most Touchdowns Rushing, Game
| 5 | Cookie Gilchrist | Buffalo vs. New York | December 8, 1963 |
| 4 | Abner Haynes | Dallas vs. Oakland | November 26, 1961 |
| 3 | By Many Players |
Most Consecutive Games with Rushing Touchdown
| 7 | Cookie Gilchrist | Buffalo (1962) |
| 6 | Paul Lowe | L.A.-S.D. (1960-61) |
| Emerson Boozer | New York (1967) | |
| 5 | Mike Garrett | Kansas City (1967) |
